Namayingo District is located along the Equator. It is bordered by Bugiri District to the northwest, Busia District to the northeast, the Republic of Kenya to the east and southeast, the Republic of Tanzania to the south and Mayuge District to the west and southwest. Namayingo, where the district headquarters are located, is approximately 95 kilometers (59 miles), by road, southeast of Jinja, the largest city in the Busoga sub-region. This location lies approximately 38 kilometers (24miles), by road, south of Bugiri, the nearest large town.
The coordinates of the district are: 00 17N, 33 51E.